PUBLICATIONS

Featured Recent Publications

Maynard, J.A., Leppla, S.H., Brasky, K., Patterson, J.L., Iverson, B.L. and Georgiou, G. (2002) Recombinant Antibody Fragment Mediated Protection to Anthrax Toxin Challenge Correlates with Antigen Affinity. Nature/Biotechnology. 20, 597–601. DOI: 10.1038/nbt0602-597.

Mabry, R., Rani, M., Geiger, R., Hubbard, G.B., Carrion R., Jr., Brasky, K., Patterson, J.L., Georgiou, G., Iverson, B.L. (2005) Passive Protection Against Anthrax Using a High Affinity Anti-Toxin Antibody, Fragment Lacking An Fc Region. Infection and Immunity. 73, 8362-8368. DOI: 10.1128/IAI.73.12.8362-8368.2005.

Mazor Y, Van Blarcom T., Mabry R., Iverson B.L., Georgiou G. (2007) Isolation of Engineered, Full-length Antibodies from Libraries Expressed in Escherichia coli Nat Biotechnol. 25(5), 563-565.

Bradford, V.J. and Iverson, B.L., (2008) Amyloid-like Behavior in Abiotic, Amphiphilic Foldamers J. Am. Chem. Soc. 130(1), 1517-1524.

Varadarajan, N., Rodriguez, S., Hwang, B.W., Georgiou, G., Iverson B.L., (2008) Highly Active and Selective Endopeptidases with Programmed Substrate Specificities, Nature Chem. Biology 4, 290-294.

Yariv Mazor, Y., Van Blarcom, T., Iverson, B.L., Georgiou, G., (2008) E-clonal antibodies: selection of full-length IgG antibodies using bacterial periplasmic display, Nature Protocols, 3, 1766-1777.

Varadarajan, N., Georgiou, G., Iverson B.L., (2008) An Engineered Protease that Cleaves Specifically After Sulfated Tyrosine”, Angewandte Chemie-Int. Ed., 47, 7861-7863.

Chu, Y., Hoffman, D.W., and Iverson, B.L. (2009) A Pseudocatenane Structure Formed between DNA and a Cyclic Bisintercalator”, J. Am. Chem. Soc., 131, 3499-3508.

Pogson, M., Georgiou, G., Iverson B.L., (2009) Engineering next generation proteases, Current Op. in Biotech., 20, 390-397.

Varadarajan, N., Pogson, M., Georgiou, G., and Iverson, B.L. (2009) Proteases That Can Distinguish among Different Post-translational Forms of Tyrosine Engineered Using Multicolor Flow Cytometry J. Am. Chem. Soc., 131, 18186-18190.

Leysath, C.E., Monzingo, A.F., Maynard, J.A., Barnett, J., Georgiou, G., Iverson, B.L., and Robertus, J., (2009) Crystal Structure of the Engineered Neutralizing Antibody M18 Complexed to Domain 4 of the Anthrax Protective Antigen. J. Mol. Bio., 387, 680-693. DOI: 10.1016/j.jmb.2009.02.003.

Rhoden Smith, A.; Ikkanda, B.A.: Holman, G. and Iverson, B.L. (2012) Subtle Recognition of 14-Base Pair DNA Sequences via Threading Polyintercalation. Biochemistry, 51, 4445−4452. DOI: 10.1021/bi303317n.

Martinez, C. and Iverson, B.L. (2012) Rethinking the Term ‘Pi-stacking’, Chem. Sci., 3, 2191-2201.

Rhoden Smith, A. and Iverson, B.L. (2013) Threading Polyintercalators with Extremely Slow Dissociation Rates and Extended DNA Binding Sites. J. Am. Chem. Soc., 135, 12783-12789. DOI: 10.1021/ja4057344.

Peebles, C., Piland, R., and Iverson, B.L. (2013) More than Meets the Eye: Conformational Switching of a Stacked Dialkoxynaphthalene Naphthalenetetracarboxylic diimide (DAN–NDI) Foldamer to an NDI–NDI Fibril Aggregate. Chemistry, a European Journal. 19, 11598–11602/ PMID:23853102; DOI: 10.1002/chem.201302009.

Yi, L., Gebhard, M.C., Li. Q., Taft, J., Georgiou, G. and Iverson, B.L. (2013) Engineering of TEV protease Variants by Yeast ER Sequestration Screening (YESS) of Combinatorial Libraries. Proc. of Nat. Acad. Sci. USA, 110, 7229-7234. PMID 23589865 DOI:10.1073/pnas.1215994110.

Ikkanda, B. and Iverson B.L. (2014) NDI and DAN DNA: Nucleic Acid Directed Assembly of NDI and DAN. Org. Chem., 79, 2029–2037. DOI: 10.1021/jo402704z.

Peebles, C., Alvey, P.M., Lynch, V. and Iverson, B.L. (2014) Time-Dependent Solid-State Polymorphism of a Series of Donor–Acceptor Dyads. Cryst. Growth and Design, 14 290–299. PMID: 24678269; DOI: 10.1021/cg401522v.

Yi,L., Taft, JM., Li, Q., Gebhard, MC., Georgiou, G., Iverson, B.L. (2015) Yeast Endoplasmic Reticulum Sequestration Screening for the Engineering of Proteases from Libraries Expressed in Yeast. Methods Mol Biol. 1319:81-93. DOI: 10.1007/978-1-4939-5748.

Ikkanda, B.A and Iverson, B.L. (2016) Exploiting the Interactions of Aromatic Units for Folding and Assembly in Aqueous Environments. Chem Comm., 52, 7752-7759. PMID: 27080050; DOI: 10.1039/c6cc01861k

Li, Q., Yi, L., Hoi, KH., Marek, P., Georgiou, G., Iverson, B.L. (2017) Profiling Protease Specificity: Combining Yeast ER Sequestration Screening (YESS) with Next Generation Sequencing. ACS Chem Biol. 12(2):510-518. DOI:10:1021/acschembio.6b00547.

Taft JM, Georgeon S, Allen C, Reckel S, DeSautelle J, Hatchell O, Georgiou G, Iverson BL. (2019) Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity. ACS Chem Biol., 14(9):1888-1895, doi: 10.1021/acschembio.9b00283. PMID: 31339688.

Wight, CD., Xiao, Q., Wagner, HR., Hernandez, EA., Lynch, VM., Iverson, B.L. (2020) Mechanistic Analysis of Solid-State Colorimetric Switching: Monoalkoxynaphthalene-Naphthalimide Donor-Acceptor Dyads. J. Am. Chem. Soc., 142(41), 17630-17643. PMID: 32897707; DOI: 10.1021/jacs.0c08137.

C. A. Denard, C. Paresi, R. Yaghi, N. McGinnis, Z. Bennett, L. Yi, G. Georgiou, and B. L. Iverson (2021) YESS 2.0, a Tunable Platform for Enzyme Evolution, Yields Highly Active TEV Protease Variants, ACS Syn. Biol. 10, 1, 63-71. DOI: 10.1021/acssynbio.0c00452

Wi. Voss, Y. Hou, N. Johnson, G. Delidakis, JE Kim, K. Javanmardi, A. Horton, F. Bartzoka, C. Paresi, Y. Tanno, C-W. Chou, S. Abbasi, W. Pickens, K. George, D. Boutz, D. Towers, J. McDaniel, D. Billick, J. Goike, L. Rowe9, D. Batra, J. Pohl, J. Lee, S. Gangappa, S. Sambhara, M. Gadush, N. Wang, M. Person, B. L. Iverson, J. Gollihar, J. Dye, A. Herbert, I. Finkelstein, R. Baric, J. McLellan, G. Georgiou, J. Lavinder, G. Ippolito, (2021) Prevalent, Protective, and Convergent IgG Recognition of SARS-CoV-2 non-RBD Spike Epitopes Science, 372, Issue 6546, 1108-1112 DOI: 10.1126/science.abg5268

Raulerson EK, Cadena DM, Jabed MA, Wight CD, Lee I, Wagner HR, Brewster JT, Iverson BL, Kilina S, Roberts ST. Using spectator ligands to enhance nanocrystal-to-molecule electron transfer. J Phys Chem Lett. 2022;13(6):1416-1423. doi:10.1021/acs.jpclett.1c03825. PMID: 35119280.

Bachman JL, Wight CD, Bardo AM, Johnson AM, Pavlich CL, Boley AJ, Wagner HR, Swaminathan J, Iverson BL, Marcotte EM, Anslyn EV. Evaluating the effect of dye-dye interactions of xanthene-based fluorophores in the fluorosequencing of peptides. Bioconjug Chem. 2022;33(6):1156-1165. doi:10.1021/acs.bioconjchem.2c0010. PMID: 35622964.

Wight CD, Xiao Q, Wagner HR, Hernandez EA, Martin E, Lynch VM, Iverson BL. Influence of the alkyl side chain length on the assembly and thermochromic solid-state properties in symmetric and asymmetric monoalkoxynaphthalene-naphthalimide donor-acceptor dyads. Cryst Growth Des. 2022;22(12):7363-7373. doi:10.1021/acs.cgd.2c00977.

Cadena DM, Sowa JK, Cotton DE, Wight CD, Hoffman CL, Wagner HR, Boette JT, Raulerson EK, Iverson BL, Rossky PJ, Roberts ST. Aggregation of charge acceptors on nanocrystal surfaces alters rates of photoinduced electron transfer. J Am Chem Soc. 2022;144(49):22676-22688. doi:10.1021/jacs.2c09758. PMID: 36450151.

Zhang L, Krause TB, Deol H, Pandey B, Xiao Q, Park HM, Iverson BL, Law D, Anslyn EV. Chemical and linguistic considerations for encoding Chinese characters: an embodiment using chain-end degradable sequence-defined oligourethanes created by consecutive solid phase click chemistry. Chem Sci. 2024;15(14):5284-5293. doi:10.1039/d3sc06189b. PMID: 38577351.

Yaghi RM, Andrews CL, Wylie DC, Iverson BL. High-resolution substrate specificity profiling of SARS-CoV-2 Mpro: comparison to SARS-CoV Mpro. ACS Chem Biol. 2024;19(7):1474-1483. doi:10.1021/acschembio.4c00096. PMID: 38865301; PMCID: PMC11267570.

Yaghi RM, Wylie DC, Andrews CL, Dickert OH, Ram A, Iverson BL. An investigation of nirmatrelvir (Paxlovid) resistance in SARS-CoV-2 Mpro. ACS Bio Med Chem Au. 2024;4(6):280-290. doi:10.1021/acsbiomedchemau.4c00045. PMID: 39712205. Selected as an ACS Editor’s Choice article.

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Xiao Q, Herbst MR, Vasylevskyi S, Lynch VM, Iverson BL. Readily observable morphological changes in monoalkoxynaphthalene-naphthaleneimide donor-acceptor dyad crystals induced by specific H/D substitution. Cryst Growth Des. 2025;25:3452-3463. doi:10.1021/acs.cgd.5c00302.

Levine MS, Sen S, Maier EY, Mota M, Won M, Li J, Arambula JF, Lynch VM, Kim JS, DePinho RA, Iverson B, Sessler JL. Long-lived immunogenic cell death induced by a water-soluble redox active Au(I) bis-N-heterocyclic carbene. J Am Chem Soc. 2025;147(27):23574-23582. doi:10.1021/jacs.5c03455. Epub 2025 Jun 26. PMID: 40570165.

Levine, MS, Jiexi Li, J, Ehrlich, LIR, Ronald A. DePinho, RA, Iverson, BL, Sessler, JL Viral mimicry may help explain immunogenic cell death Proc Natl Acad Sci U S A. 2026 Vol. 123 No. 11 e2537547123 https://doi.org/10.1073/pnas.2537547123.

Click here to read a press release about the PNAS paper

Xiao, Q, Levine, MS, Iverson BL Rethinking the terms “π-stacking” and “π-π stacking” again: A proposal to clarify the language of aromatic interactions. J Am Chem Soc. 2026; 148 (15): 15331–15340. https://doi.org/10.1021/jacs.6c03371